Coronavirus humains (HCoV)
Identifieur interne : 003143 ( Main/Exploration ); précédent : 003142; suivant : 003144Coronavirus humains (HCoV)
Auteurs : A. Vabret [France] ; J. Dina [France] ; E. Brison [France] ; J. Brouard [France] ; F. Freymuth [France]Source :
- Pathologie-Biologie [ 0369-8114 ] ; 2008.
Descripteurs français
- KwdFr :
- Amérique du Nord (épidémiologie), Animaux, Asie (épidémiologie), Coronavirus (génétique), Coronavirus (pathogénicité), Coronavirus (ultrastructure), Génome viral, Humains, Hépatite virale animale (virologie), Infections à coronavirus (médecine vétérinaire), Infections à coronavirus (transmission), Infections à coronavirus (épidémiologie), Mammifères, Syndrome respiratoire aigu sévère (épidémiologie), Transmission de maladie infectieuse, Virus du SRAS (pathogénicité).
- MESH :
- génétique : Coronavirus.
- médecine vétérinaire : Infections à coronavirus.
- pathogénicité : Coronavirus, Virus du SRAS.
- virologie : Hépatite virale animale.
- épidémiologie : Amérique du Nord, Asie, Coronavirus, Infections à coronavirus, Syndrome respiratoire aigu sévère.
- Animaux, Génome viral, Humains, Mammifères, Transmission de maladie infectieuse.
English descriptors
- KwdEn :
- Animals, Asia (epidemiology), Coronavirus (genetics), Coronavirus (pathogenicity), Coronavirus (ultrastructure), Coronavirus Infections (epidemiology), Coronavirus Infections (transmission), Coronavirus Infections (veterinary), Disease Transmission, Infectious, Genome, Viral, Hepatitis, Viral, Animal (virology), Humans, Mammals, North America (epidemiology), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (epidemiology).
- MESH :
- epidemiology : Asia, Coronavirus Infections, North America, Severe Acute Respiratory Syndrome.
- genetics : Coronavirus.
- pathogenicity : Coronavirus, SARS Virus.
- transmission : Coronavirus Infections.
- ultrastructure : Coronavirus.
- veterinary : Coronavirus Infections.
- virology : Hepatitis, Viral, Animal.
- Animals, Disease Transmission, Infectious, Genome, Viral, Humans, Mammals.
Abstract
Les coronavirus forment un grand groupe de virus infectant les mammifères et les oiseaux ; cinq d’entre eux infectent l’homme : HCoV 229E et OC43, connus depuis les années 1960, SARS-CoV identifié en mars 2003 lors de l’épidémie de syndrome de détresse respiratoire aigu sévère, NL63 et HKU1, identifiés respectivement en 2004 et 2005. Ce sont des virus enveloppés dont le génome est une molécule d’ARN de polarité positive de très grande taille. Leur mode évolutif fait intervenir plusieurs paramètres : la génération de nombreux mutants lors de la réplication, responsable d’une distribution en quasi-espèces de la population virale, la capacité à établir des infections persistantes, la possibilité de délétions importantes, la grande flexibilité du génome due à un fort taux de recombinaisons homologues et hétérologues, la capacité à franchir les barrières d’espèces et à s’adapter au nouvel environnement. Les coronavirus (hors SARS-CoV) sont ubiquitaires et circulent sous forme épidémique. Les différents HCoV co-circulent avec une distribution entre les types qui est variable selon les années et les régions géographiques. Ce sont essentiellement des virus responsables d’infections respiratoires hautes et basses. Le SARS-CoV est, lui, un virus émergent responsable de l’épidémie de pneumopathies atypiques entre novembre 2002 et juillet 2003. Sa circulation a été interrompue grâce à la mise en place de mesures sanitaires drastiques. L’implication des HCoV dans des pathologies digestives et neurologiques reste à préciser. La détection des coronavirus est difficile, et fait appel surtout à des techniques moléculaires. Il n’existe actuellement aucun traitement spécifique des infections à HCoV.
Url:
DOI: 10.1016/j.patbio.2008.02.018
PubMed: 18456429
PubMed Central: 7125620
Affiliations:
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Le document en format XML
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Vabret</name><affiliation wicri:level="3"><nlm:aff id="aff1">Laboratoire de virologie, EA 2128, centre hospitalo-universitaire de Caen, avenue Georges-Clemenceau, 14033 Caen cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de virologie, EA 2128, centre hospitalo-universitaire de Caen, avenue Georges-Clemenceau, 14033 Caen cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Dina, J" sort="Dina, J" uniqKey="Dina J" first="J." last="Dina">J. Dina</name><affiliation wicri:level="3"><nlm:aff id="aff1">Laboratoire de virologie, EA 2128, centre hospitalo-universitaire de Caen, avenue Georges-Clemenceau, 14033 Caen cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de virologie, EA 2128, centre hospitalo-universitaire de Caen, avenue Georges-Clemenceau, 14033 Caen cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Brison, E" sort="Brison, E" uniqKey="Brison E" first="E." last="Brison">E. 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Brouard</name><affiliation wicri:level="3"><nlm:aff id="aff2">Service de pédiatrie, centre hospitalo-universitaire de Caen, avenue Georges-Clemenceau, 14033 Caen cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de pédiatrie, centre hospitalo-universitaire de Caen, avenue Georges-Clemenceau, 14033 Caen cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Freymuth, F" sort="Freymuth, F" uniqKey="Freymuth F" first="F." last="Freymuth">F. Freymuth</name><affiliation wicri:level="3"><nlm:aff id="aff1">Laboratoire de virologie, EA 2128, centre hospitalo-universitaire de Caen, avenue Georges-Clemenceau, 14033 Caen cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de virologie, EA 2128, centre hospitalo-universitaire de Caen, avenue Georges-Clemenceau, 14033 Caen cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author></analytic><series><title level="j">Pathologie-Biologie</title><idno type="ISSN">0369-8114</idno><idno type="eISSN">1768-3114</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Asia (epidemiology)</term><term>Coronavirus (genetics)</term><term>Coronavirus (pathogenicity)</term><term>Coronavirus (ultrastructure)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (transmission)</term><term>Coronavirus Infections (veterinary)</term><term>Disease Transmission, Infectious</term><term>Genome, Viral</term><term>Hepatitis, Viral, Animal (virology)</term><term>Humans</term><term>Mammals</term><term>North America (epidemiology)</term><term>SARS Virus (pathogenicity)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Amérique du Nord (épidémiologie)</term><term>Animaux</term><term>Asie (épidémiologie)</term><term>Coronavirus (génétique)</term><term>Coronavirus (pathogénicité)</term><term>Coronavirus (ultrastructure)</term><term>Génome viral</term><term>Humains</term><term>Hépatite virale animale (virologie)</term><term>Infections à coronavirus (médecine vétérinaire)</term><term>Infections à coronavirus (transmission)</term><term>Infections à coronavirus (épidémiologie)</term><term>Mammifères</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Transmission de maladie infectieuse</term><term>Virus du SRAS (pathogénicité)</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Asia</term><term>Coronavirus Infections</term><term>North America</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Hépatite virale animale</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Hepatitis, Viral, Animal</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Amérique du Nord</term><term>Asie</term><term>Coronavirus</term><term>Infections à coronavirus</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Transmission, Infectious</term><term>Genome, Viral</term><term>Humans</term><term>Mammals</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Génome viral</term><term>Humains</term><term>Mammifères</term><term>Transmission de maladie infectieuse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Résumé</title><p>Les coronavirus forment un grand groupe de virus infectant les mammifères et les oiseaux ; cinq d’entre eux infectent l’homme : HCoV 229E et OC43, connus depuis les années 1960, SARS-CoV identifié en mars 2003 lors de l’épidémie de syndrome de détresse respiratoire aigu sévère, NL63 et HKU1, identifiés respectivement en 2004 et 2005. Ce sont des virus enveloppés dont le génome est une molécule d’ARN de polarité positive de très grande taille. Leur mode évolutif fait intervenir plusieurs paramètres : la génération de nombreux mutants lors de la réplication, responsable d’une distribution en quasi-espèces de la population virale, la capacité à établir des infections persistantes, la possibilité de délétions importantes, la grande flexibilité du génome due à un fort taux de recombinaisons homologues et hétérologues, la capacité à franchir les barrières d’espèces et à s’adapter au nouvel environnement. Les coronavirus (hors SARS-CoV) sont ubiquitaires et circulent sous forme épidémique. Les différents HCoV co-circulent avec une distribution entre les types qui est variable selon les années et les régions géographiques. Ce sont essentiellement des virus responsables d’infections respiratoires hautes et basses. Le SARS-CoV est, lui, un virus émergent responsable de l’épidémie de pneumopathies atypiques entre novembre 2002 et juillet 2003. Sa circulation a été interrompue grâce à la mise en place de mesures sanitaires drastiques. L’implication des HCoV dans des pathologies digestives et neurologiques reste à préciser. La détection des coronavirus est difficile, et fait appel surtout à des techniques moléculaires. Il n’existe actuellement aucun traitement spécifique des infections à HCoV.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y. Huang</name></author><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Almeida, J D" uniqKey="Almeida J">J.D. 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Li</name></author><author><name sortKey="Maes, P" uniqKey="Maes P">P. Maes</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Basse-Normandie</li><li>Région Normandie</li></region><settlement><li>Caen</li></settlement></list><tree><country name="France"><region name="Région Normandie"><name sortKey="Vabret, A" sort="Vabret, A" uniqKey="Vabret A" first="A." last="Vabret">A. Vabret</name></region><name sortKey="Brison, E" sort="Brison, E" uniqKey="Brison E" first="E." last="Brison">E. Brison</name><name sortKey="Brouard, J" sort="Brouard, J" uniqKey="Brouard J" first="J." last="Brouard">J. Brouard</name><name sortKey="Dina, J" sort="Dina, J" uniqKey="Dina J" first="J." last="Dina">J. Dina</name><name sortKey="Freymuth, F" sort="Freymuth, F" uniqKey="Freymuth F" first="F." last="Freymuth">F. Freymuth</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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